Calprotectin (S100A8/A9) in Familial Mediterranean Fever
نویسندگان
چکیده
Introduction Calprotectin (S100A8/A9) is an example of a damage associated molecular pattern and a TLR4 ligand. It is expressed in neutrophils, monocytes and early infiltrating macrophages. Calprotectin, once secreted, has a number of proinflammatory effects on activated endothelium and on phagocytes and reflects activation of the innate immune system. Calprotectin has been demonstrated to be secreted during inflammation and play a role in a number of inflammatory diseases. In view of calprotectin reflecting monocyte activation, we aimed to investigate calprotectin in patients with Familial Mediterranean Fever (FMF).
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